Zebrafish Diseases
Zebrafish have become a very important model for studies in developmental biology. Center members at OSU and the Zebrafish International Resource Center, University of Oregon (http://zfin.org/zf_info/stckctr/stckctr.html) have active programs investigating the cause of diseases of zebrafish, supported by NIH National Center for Research Resources. See our on-line manual on diseases of zebrafish (http://zfin.org/cgi-bin/webdriver?MIval=aa-ZDB_home.apg)
Pseudoloma neurophilia. A prevalent microsporidian infecting the central nervous system of zebrafish. A - C. Transmission electron micrographs. A. prespores stages (ps) and sporont (s); B, mature
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Pseudocapillaria tormentosa. A capillarid nemotode of cyprinid fishes, causes gut lesions in zebrafish.
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Mycobacteriosis (Fish TB) caused by Mycobacterium spp. Bacteria occur within well-organized granulomas and are acid-fast positive (i.e., they stain red with the acid fast stain). Mycobacteria infections occur in a wide variety of cultured and wild fishes, including aquarium fishes, salmonids, rockfish and striped bass.
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Hepatic megalocytosis. This condition is characterized by tremendous enlargement of the cytoplasm and nuclei of hepatocytes (H), and is generally thought to be caused by hepatoxicants, both anthropogenic and natural toxins, such as microcystin from cyanobacteria.
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Spindle cell sarcoma. We have observed several neoplasms in zebrafish. At present, their cause is unknown. One of the most common are spindle cell sarcomas (neurofibroma-like tumors) of the viscera and eye.
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